The Importance of Glutathione

 

Glutathione is a small protein molecule, or tri-peptide. Glutathione is found in a large quantity in the liver and it plays a key role in supporting the immune system. Medical experts say that glutathione is the most effective and efficient endogenous anti-oxidant. It is important to note that the accumulation of oxidative damage which is a biochemical mechanism is closely related to aging. There is a direct relationship between the decrease of glutathione concentrations and aging. Most scientists are now convinced that a high level of glutathione will reduce the rate of aging, detoxify your liver, support immune system and protect body cells from free radicals.

 

Free radicals are created in many different ways with a variety of causes, ranging from the air we breathe to the food we eat to the sun that tans our skin. The body’s ability to defuse these ticking time bombs relies on the deployment of various antioxidants that sweep through our system and dismantle these potential threats before they can damage any cells.

 

The Body's Master Antioxidant glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and an antitoxin and is a major defence system against illness and aging. Our glutathione level actually indicates our state of health and may be an important factor in determining longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine because it is a naturally occurring substance found within the body. Hence there is no money to be made by drug companies in researching into any natural product that may help build levels of glutathione in the body. In the near future the importance of glutathione will be widely recognised because it has the ability to dramatically boost the immune system and fight off the damage free radicals wreak on cells and the immune system.

 

Glutathione is recognised by the scientific community as the most powerful and prevalent antioxidant in the human body.

 

Glutathione has been shown to slow down the aging process, detoxify and improve liver function, strengthen the immune system, and reduce the chances of developing cancer. Glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.

 

Important Roles of Glutathione:

• Fights against oxidative cell damage (from free radicals)
• Immune system enhancement
• Amino acid transport
• Cellular detoxification
• Protein synthesis
• Fights cellular Inflammation
• Enzyme activation
• ATP (energy) production

Important to know that supplements containing glutathione alone will not increase the body’s glutathione levels - because the digestive system breaks down ingested glutathione and it will not be absorbed into your system. The good new is that RESURGEN® provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione.

 

Glutathione benefits:

Immune System: Immune Depressed individuals have lower GSH levels when fighting disease. Lymphocytes, cells vital for your immune response, depend on GSH for their proper function and replication. Glutathione is essential in supporting the immune system, including natural killer cells.

Cancer: GSH plays a role in eliminating many carcinogens as well as maintaining immune function towards providing stronger anti-tumor defenses.

Glutathione and the Liver: Regarding the safety of glutathione in the liver, it is said that the levels of glutathione in the liver is critically linked to the liver s capacity to detoxify. This means that the higher the glutathione content, the greater the liver s capacity to detoxify harmful chemicals. Typically, when we are exposed to chemicals like alcohol which can damage the liver, the concentration of glutathione in the liver is substantially reduced. This reduction makes the liver susceptible to damage.

Antioxidant Functions: Antioxidants are well documented to play vital roles in health maintenance and disease prevention. GSH is our cell's own major antioxidant.

Athletes: Strong muscular activity generates oxyradicals leading to muscle fatigue and poorer performance. GSH neutralizes these radicals.Recent research indicates that propensities toward many degenerative diseases and aging itself are related to the capacity of the cell to robustly recover from oxidative insult. The capacity of a cell to recover from such insult can be determined by measuring the intracellular stores of Glutathione.

Aging Process: It is known that as we age, there is a precipitous drop in GSH levels. Lower Glutathione levels are implicated in many diseases associated with aging, including Cataracts, Alzheimer's disease, Parkinson's, arteriosclerosis and others.

Toxins, Pollution, Radiation: GSH detoxifies many pollutants, carcinogens and poisons, including many in fuel exhaust and cigarette smoke. It retards damage from radiation such as seen with loss of the ozone. The liver is the main detoxification organ of the body. In the liver we find very high concentrations of GSH, as it is a major factor in numerous biochemical detoxification pathways. Numerous studies have demonstrated that patients with compromised liver function due to alcohol abuse have significant reduction of GSH in the liver.

Neurological Disease: Low GSH has been demonstrated in nuerodegenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's Disease), Alzheimer's, and Parkinson's, among others.

Diabetes: Glutathione improved insulin secretion from the pancreas in response to increased blood sugar in older patient with impaired glucose tolerance. Because of this effect glutathione may show in the future to help restore normal blood sugar metabolism.

AIDS: Low Glutathione levels with poor survival in AIDS patients. Much literature has been written demonstrating the role of enhancing GSH levels in AIDS.

Atherosclerosis: In patients with Atherosclerosis IV Glutathione was shown to significantly decrease blood viscosity and significantly increase blood filtration.

Parkinson's:Studies have shown that Parkinson’s patients have decreased glutathione levels in the substantia nigra region of the brain. The amount of glutathione depletion seems to parallel the severity of the patients symptoms so people with lower levels of glutathione have more severe symptoms. In a study of patients with early Parkinson’s disease who were treated with Glutathione for 1 month all patients improved significantly with a 42% decline in disability. These improvements in symptoms lasted for 2-4 months after the Glutathione was stopped. Glutathione may retard progression of this disease.

 

References:
 1. B. Donnerstag et al., “Reduced Glutathione and S-acetylglutathione as Selective Apoptosis-Inducing Agents in Cancer Therapy,” Cancer Letters 110 (1-2):63-70 (1996)
 2. J F Smyth et al., “Glutathione Reduces the Toxicity and Improves Quality of Life of Women Diagnosed with Ovarian Cancer Treated with cisplatin. Results of a Double-blind, Randomized Trial,” Annals of Oncology 8(6):569-73 (1997)
 3. M. Tedeschi et al., “Glutathione and Detoxification,” Cancer Treatment Review 17(2-3):203-8 (1990)
4. E. Ciuchi et al., “The Effect of Acute Glutathione Treatment on Sorbitol level in Erythro cytes from Diabetic Patients”, Diabetes Metab Feb 23 (1):58-60 (1997)
 5. A Ceriello et al., “Antioxidants show an Anti-hypertensive Effect in Diabetic and Hypertensive Subjects,” Clin Sci, Dec; 81 (6):739-42 (1991)
 6. G. Pao lasso et al., “Glutathione Infusion Potentiates Glucose Induced Iinsulin Secretion in Aged Patients with Iimpaired Glucose Tolerance,” Diabetes care, Jan; 15(1):1-7 (1992)
 7. P. Dentico et al., “Glutathione in the Treatment of Chronic Fatty Liver Diseases,” Recenti Prog Med, Jul-Aug; 86 (7-8):290-3 (1995)       
 8. H. Yoshida et al., “Effects of Glutathione Isopropyl Ester on Bile Flow in Glutathione Depleted Rats,” Arch Int Pharmacodyn Ther, Mar-Apr; 322:105-19 (1993)
 9. G. Sechi et al., “Reduced Intravenous Glutathione in the Treatment of Early Parkinson’s Disease,” Prog Neuropsy chopharmacol Biol Psychiatry, Oct; 20(7):1159-70 (1996)
 10. l. Coppola et al., “Glutathione improved Haemo static and Haemorheological Parameters in Atherosclerotic Subjects,” Drugs Exp Clin Res, 18(11-12):493-8 (1992)
 11. PS Samiec et al., “Glutathione in Human Plasma: Decline in Association with Aging, Age related Macular Degeneration, Diabetes,” Free Radic Biol Med mar15:24(5):699-704 (1998)

 

More sientific information:

Overcome the metabolic acidosis. The mother of all diseases: Metabolic acidosis and its amendment

Medical Publications on Glutatione

Hyperhomocysteinema Treatment

Bovine Calostrum In Cancer Treatment

The Free Radicals Theory And Oxidative Stress On Aging

Soy Isoflavones And Cancer

Nitric Oxide Decrease and Homocysteine and Free Radicals Increase as Diseases Producer Agents and Their Regulation by Resurgen

Arteriosclerosis

Glutatione and cancer

Magnetized water

The importance of glutathione in human disease

 

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